What is the normal function of miR-21, miR-375, and miR-141 in healthy cells?

In healthy cells, miR-21 plays a role in normal inflammatory responses and wound healing — it transiently rises during acute stress and then returns to baseline. miR-375 is involved in pancreatic beta-cell development and glucose homeostasis. miR-141 is part of the miR-200 family, which regulates epithelial cell identity and suppresses the epithelial-to-mesenchymal transition (EMT) — a process involved in both development and cancer metastasis. In cancer, each of these miRNAs is dysregulated in ways that promote tumor growth: miR-21 becomes chronically overexpressed, suppressing tumor suppressor genes; miR-375 overexpression in prostate cancer promotes androgen-independent growth; and miR-141 overexpression has been linked to metastatic spread in prostate and colorectal cancer.