CLIA-Certified · Laboratory Developed Test · No Prescription Required

The OncuraKit.
Everything you need to know.

A single urine sample. Three validated cancer miRNA biomarkers. Six cancer types. The highest published Stage I/II sensitivity of any multi-cancer early detection test.

What's In Your Kit

Everything you need, nothing you don't.

Your OncuraKit arrives in discreet, plain packaging with everything required for a simple, safe, at-home urine collection and pre-paid overnight return to Yenos Analytical in California.

  • Sterile 10 mL urine specimen collection cup
  • Temperature-stable specimen preservation media (Yenos-validated)
  • Absorbent pad and bio-safe specimen pouch
  • Printed step-by-step collection instructions
  • Pre-addressed bio-mailer with overnight return label (pre-paid)
  • Tamper-evident seal stickers
  • Chain-of-custody form (filled out by you, reviewed by lab)
Lab Location

Yenos Analytical LLC

El Dorado Hills, California · CLIA-Certified
Founded by Dr. Anastassia Kanavarioti (UC Santa Cruz)
3 NIH SBIR Phase I Grants · 3 US Patents Granted

PlatformMinION/Yenos Nanopore
Nanopores per flow cell2,048
Baseline current180 pA
Amplification required?No — single molecule
Published studies4 (2020–2025)
Deep dive into the science

What the test measures

Three cancer-associated microRNAs, each validated across more than 700 published studies and 70,000 patient samples — plus one internal control.

Published: ijms26083822 (2025)

Cancer Biomarker

miR-21-5p

Per-marker accuracy93.8%

36/37 · 700+ validation studies

One of the most studied oncogenic miRNAs globally. Overexpressed in virtually all cancer types, including prostate, breast, colorectal, pancreatic, lung, and ovarian.

Published study
Cancer Biomarker

miR-375-3p

Per-marker accuracy81.5%

Validation cohort · 700+ validation studies

Validated cancer-associated miRNA linked to prostate, esophageal, gastric, and pancreatic cancer. Functions as both oncogene and tumor suppressor depending on tissue context.

Published study
Cancer Biomarker

miR-141-3p

Per-marker accuracy97.3%

Top accuracy · 700+ validation studies

Highest per-marker accuracy in the Yenos panel. Strongly associated with prostate cancer and colorectal cancer progression. Member of the miR-200 family.

Published study
Internal Control

miR-15b-5p

Not a cancer marker — validates test integrity

Used exclusively as an internal control to verify the test ran correctly. miR-15b-5p levels should NOT change between healthy and cancer samples — confirming test validity.

Zero overlap between cancer and healthy populations

Cancer samples express these miRNAs at 1.83× the Healthy Level (HL). Healthy samples express at 1.04× HL. The 1.5× HL threshold sits clearly between both groups — with zero data overlap between populations (p=1.6×10⁻²²). No other MCED test has published zero data overlap.

See the full data
Cancer avg.1.83× HL
Threshold1.5× HL
Healthy avg.1.04× HL

p=1.6×10⁻²² · Int. J. Mol. Sci. 2025

From order to results in 7–12 days

No waiting rooms. No appointments. Just a clear path from your home to our California lab.

1
Day 1

Order online at Oncura.health

2-minute checkout. No prescription required.

2
Days 2–3

Kit arrives at your door

Shipped in discreet, plain packaging.

3
Day 3–4

Collect your urine sample

5 minutes. No clinic. No needles. At home.

4
Day 4–5

Drop pre-paid mailer at any USPS or FedEx location

Pre-paid overnight shipping to El Dorado Hills, CA.

5
Days 5–6

Yenos Analytical receives and processes your sample

MinION/Yenos nanopore analysis. CLIA-certified.

6
Days 7–12

Results delivered to your private dashboard

Detailed lab report with exact HL scores and classification.

Your Results Report

Clear, actionable results in your secure dashboard.

Your report from Yenos Analytical is delivered to your private OncuraKit dashboard within 5–7 days of the lab receiving your sample. It contains:

  • Exact HL score for each of the three cancer miRNAs
  • Pass / Elevated classification per marker
  • Overall result: Normal or Elevated
  • Internal control validity confirmation (miR-15b-5p)
  • Full Yenos Analytical chain-of-custody documentation
  • Physician-ready interpretation summary

Important: A positive (elevated) result is a screening signal, not a diagnosis. We provide a complimentary physician consultation to walk through any elevated result and guide appropriate follow-up. Read the FAQs →

OncuraKit Results Dashboard

Sample ID: YNS-2025-04891

Normal
miR-21-5p1.02× HLNormal
miR-375-3p0.98× HLNormal
miR-141-3p1.11× HLNormal
miR-15b-5pControl Valid
Result bar1.5× HL threshold

Analyzed by Yenos Analytical LLC · CLIA # [on file] · El Dorado Hills, CA

Pricing
$995/ one-time

No subscription. No recurring charges. You own your results.

Everything included:

  • Kit shipping to your home
  • All collection materials
  • Overnight pre-paid return shipping
  • CLIA-certified lab analysis at Yenos Analytical
  • Secure digital results report
  • Physician consultation (if results are elevated)

HSA / FSA Eligible

OncuraKit is likely HSA/FSA eligible when ordered through a physician. We provide a detailed itemized receipt after purchase that you can submit to your HSA/FSA provider. We recommend confirming eligibility with your plan administrator first.

Employer & Group Pricing

Companies and healthcare organizations can access bulk pricing, HR reporting tools, and a dedicated account manager for employee wellness programs.

Is OncuraKit right for you?

Who should take this test

  • Adults aged 60 and older (1 in 100 are likely to develop cancer)
  • Anyone with an inconclusive mammogram, PSA test, or colonoscopy result
  • Adults who want a documented, timestamped health baseline
  • People with a family history of prostate, breast, colorectal, pancreatic, ovarian, or lung cancer
  • Adults who cannot tolerate blood draws or invasive procedures

Who should NOT take this test

  • Pregnant women (miRNA levels are naturally altered during pregnancy)
  • People currently in active cancer treatment (chemotherapy or radiation alter miRNA)
  • People on hormonal therapy (hormonal agents affect miRNA expression profiles)

If you are unsure whether you are eligible, please consult your physician before ordering. OncuraKit is a screening tool — not a diagnostic test — and should be used in conjunction with regular medical care.

Patients and healthcare professionals

Ready to take the next step in your health?

Join thousands who've chosen proactive screening. Order your OncuraKit today — private, simple, and backed by Nobel Prize-winning science.