How can microRNA be detected in urine?

MicroRNA molecules are stable in urine because they circulate as extracellular miRNAs packaged in exosomes, microvesicles, and protein-RNA complexes that protect them from RNase degradation. Yenos Analytical discovered a critical finding: miRNA levels in urine are proportional to total RNA content regardless of age, sex, or ethnicity — and after normalization using the Healthy Level (HL) reference, urine and blood miRNA levels are statistically comparable. This means urine is a valid, non-invasive alternative to blood for this class of test. The OncuraKit collection process uses Yenos-validated specimen preservation media to maintain miRNA stability during overnight shipping from your home to the California laboratory.