Is urine-based microRNA testing as accurate as blood-based testing?

Yes — according to published data from Yenos Analytical. The Yenos team demonstrated that after normalization to the Healthy Level (HL) reference standard, miRNA levels measured from urine are statistically comparable to those measured from blood. The 2025 study (doi:10.3390/ijms26083822) validating miR-21, miR-375, and miR-141 accuracy was conducted using urine samples and produced per-marker accuracy rates of 93.8%, 81.5%, and 97.3% respectively — with zero data overlap between cancer and healthy populations (p=1.6×10⁻²²). No blood-based MCED test has published zero data overlap. The advantage of urine is significant: it can be collected at home, non-invasively, without a clinic visit or a needle.