Why does OncuraKit use three miRNA markers instead of just one?

Using three independent cancer-associated miRNA markers serves two purposes: it increases sensitivity (the ability to detect cancer that is present) and it enables a second-test specificity protocol. Each marker independently confirms the cancer signal: if two or three markers are elevated, the probability that the result is a true positive is dramatically higher than if only one marker is elevated. Additionally, by running a second test on the same urine sample for any elevated result, Yenos achieves a specificity exceeding 99.9%. The three markers were selected from the most validated oncogenic miRNAs in the literature — miR-21, miR-375, and miR-141 — each documented across more than 700 studies.