Can food, supplements, or medications affect miRNA levels?

Certain dietary components and common supplements have been studied for their effects on miRNA expression, but these effects are typically modest compared to the overexpression seen in cancer. For example, curcumin, resveratrol, and omega-3 fatty acids have been shown in some studies to modulate miRNA expression — but not to levels that would push a healthy person above the 1.5× HL threshold. Over-the-counter medications and common supplements are unlikely to affect your results. The primary contraindications are hormonal therapy (including estrogen, testosterone, and hormonal birth control), active cancer treatment (chemotherapy and radiation have major effects on miRNA expression), and pregnancy. If you are uncertain about a specific medication, consult your physician before testing.