Is miRNA overexpression related to hereditary cancer risk?

People with hereditary cancer syndromes (such as BRCA1/2 mutations for breast/ovarian cancer, Lynch syndrome for colorectal cancer, or BRCA mutations for pancreatic cancer) are at elevated lifetime risk of developing cancer. MiRNA overexpression occurs when cells begin malignant transformation — it is not directly inherited or elevated simply due to carrying a cancer-predisposing mutation. However, if a BRCA carrier develops breast cancer, their tumor cells will overexpress the same miRNAs as non-hereditary breast cancer. OncuraKit is not a genetic test and does not test for inherited mutations. It is a cancer screening test that detects the molecular signal of cancer itself — regardless of the underlying cause.