How does miRNA relate to epigenetics?

Epigenetics refers to heritable changes in gene expression that do not involve changes to the DNA sequence itself — these include DNA methylation, histone modification, and regulation by non-coding RNAs including miRNAs. MiRNAs are now considered a major arm of the epigenetic regulatory network. In cancer, epigenetic silencing of tumor-suppressive miRNAs (through promoter methylation of the miRNA gene) and epigenetic activation of oncogenic miRNAs are both common. This places miRNA squarely within the epigenetic landscape of cancer. OncuraKit doesn't measure DNA methylation — it measures the functional output (the miRNA expression level) which reflects the cumulative result of all epigenetic and genetic changes in the tumor.