Can improving my lifestyle lower my miRNA levels?

Some research suggests that dietary improvements, exercise, stress reduction, and anti-inflammatory lifestyle changes can modestly affect circulating miRNA levels — including miR-21, which has roles in inflammatory signaling. However, these effects are modest compared to the overexpression seen in cancer. There is currently no evidence that lifestyle changes can significantly reduce miRNA levels that are elevated due to cancer. If your result is Normal, maintaining a healthy lifestyle is an important cancer risk reduction strategy — but it is not a substitute for screening. If your result is Elevated, pursuing lifestyle improvements is always beneficial but should never replace clinical follow-up investigation.