Can a technical failure at the lab produce a false negative result?

Technical false negatives are addressed by the multi-layer quality control process at Yenos. The internal control miRNA (miR-15b-5p) serves as the primary safeguard: if the assay fails technically (poor RNA extraction, nanopore malfunction, reagent issue), the internal control will be out of range and the sample will be flagged for re-run. The bracketing protocol independently verifies measurement accuracy within each run. Samples that do not meet quality standards are not reported — instead, the patient is notified and a repeat collection kit is sent at no charge. A biological false negative (true cancer present but miRNA below the detection threshold) is separate from a technical issue and relates to test sensitivity limitations rather than laboratory error.