Why are chemotherapy and radiation therapy contraindications?

Chemotherapy and radiation therapy cause massive cellular disruption — killing both cancer cells and rapidly dividing normal cells, triggering systemic inflammation, and releasing vast quantities of intracellular contents (including miRNA) into circulation. This dramatically and unpredictably alters the miRNA landscape in blood and urine during and for months after treatment. Because OncuraKit's HL threshold is calibrated for individuals not undergoing cytotoxic therapy, the miRNA levels during or shortly after treatment cannot be accurately interpreted against the standard reference. Additionally, people currently in cancer treatment already have a cancer diagnosis — OncuraKit is a screening tool for people without a current cancer diagnosis, not a treatment monitoring tool.