Has the Yenos nanopore platform been independently replicated by other researchers?

The Yenos nanopore miRNA quantification platform is a proprietary method, and independent replication by outside laboratories using the exact Yenos osmium tagging chemistry requires access to Yenos reagents. However, the underlying nanopore detection principle using Oxford Nanopore Technology hardware has been extensively replicated and validated by independent researchers for various nucleic acid detection applications. The biological findings of the Yenos studies (miR-21, miR-375, miR-141 overexpression in cancer) are consistent with the broader published literature from hundreds of independent research groups using conventional methods. The Yenos innovation is the detection platform (nanopore + osmium tagging + HL normalization), which is patented and has been peer-reviewed across four publications.